Start with the 07:00 FlixBus bus from Brno to Deva, about 11h 56m. Transfer in Deva, then take the 19:45 (+1d) FlixBus bus on to Bucharest (6h 45m). Transfer in Bucharest, then take the 07:00 (+1d) FlixBus bus on to İstanbul Esenler (11h 10m). You arrive in İstanbul Esenler around 18:10 (+1d). In total it's roughly EUR 180 over 35h 10m, 2 transfers.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Ground-only route to İstanbul Esenler by bus. Bus (FlixBus, 11h 56min) + Bus (FlixBus, 6h 45min) via Deva + Bus (FlixBus, 11h 10min) via Bucharest.