Start with the 07:00 FlixBus bus from Brno to Orăștie, about 13h 11m. Transfer in Orăștie, then take the 21:00 (+1d) FlixBus bus on to Bucharest (7h 30m). Transfer in Bucharest, then take the 07:00 (+1d) FlixBus bus on to İstanbul Esenler (11h 10m). You arrive in İstanbul Esenler around 18:10 (+1d). In total it's roughly EUR 191 over 35h 10m, 2 transfers.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Ground-only route to İstanbul Esenler by bus. Bus (FlixBus, 13h 11min) + Bus (FlixBus, 7h 30min) via Orăștie + Bus (FlixBus, 11h 10min) via Bucharest.