Frankfurt → Milan

Start with the 07:30 FlixBus bus from Frankfurt to Kornwestheim Post Waypoint 2, about 3h 15m. Transfer in Kornwestheim Post Waypoint 2, then take the 11:15 FlixBus bus on to Kornwestheim Pre Waypoint (15 min). Transfer in Kornwestheim Pre Waypoint, then take the 13:00 FlixBus bus on to Stuttgart West (40 min). Transfer in Stuttgart West, then take the 15:30 FlixBus bus on to Karlsruhe central (45 min). Transfer in Karlsruhe central, then take the 17:45 (+1d) FlixBus bus on to Milan (7h 20m). You arrive in Milan around 01:05 (+1d). In total it's roughly EUR 91 over 17h 35m, 4 transfers.