Start with the 07:30 FlixBus bus from Frankfurt to Karlsruhe central, about 1h 23m. Transfer in Karlsruhe central, then take the 09:15 FlixBus bus on to Darmstadt central (1h 12m). Transfer in Frankfurt, then take the 09:50 Condor flight on to Milan (1h). You arrive in Milan around 10:50. In total it's roughly EUR 119 over 12h 35m, 2 transfers.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
CondorKiwi opens sorted by price, cheapest first. Final fare is confirmed at checkout.
Fly into Frankfurt, then continue to Milan by bus (1h 23m) — routing via Frankfurt keeps the trip simple. Bus (FlixBus, 1h 23min) + Bus (FlixBus, 1h 12min) via Karlsruhe central + Flight (Condor, 1h) via Frankfurt.