Start with the 05:00 NS train from Tilburg to Amsterdam, about 1h 12m. Transfer in Amsterdam, then take the 09:15 (+1d) FlixBus bus on to Vienna (16h 25m). Transfer in Vienna, then take the 07:00 (+2d) FlixBus bus on to Sofia (17h 45m). Transfer in Sofia, then take the 07:00 (+2d) FlixBus bus on to İstanbul Esenler (8h). You arrive in İstanbul Esenler around 15:00 (+2d). In total it's roughly EUR 224 over 58h, 3 transfers.
NSOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
NS + metro
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Ground-only route to İstanbul Esenler by train + bus. Train (NS, 1h 12min) + Bus (FlixBus, 16h 25min) via Amsterdam + Bus (FlixBus, 17h 45min) via Vienna + Bus (FlixBus, 8h) via Sofia.