Start with the 08:30 AJet flight from Istanbul to Cologne, about 3h 35m. Transfer in Cologne, then take the 13:35 Regional connection bus on to Maastricht (2h 15m). Transfer in Liege, then take the 17:45 FlixBus bus on to Luxembourg (2h 5m). You arrive in Luxembourg around 19:50. In total it's roughly EUR 96 over 11h 20m, 3 transfers.
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Fly into Cologne, then continue to Luxembourg by bus (2h 15m) — routing via Cologne keeps the trip simple. Flight (VF, 3h 35min) + Bus (Regional connection, 2h 15min) via Cologne + Bus (FlixBus, 2h 5min) via Liège Guillemins.