Start with the 08:10 AJet flight from Istanbul to Zurich, about 3h 10m. Transfer in Zurich, then take the 15:30 FlixBus bus on to Freiburg (2h). Transfer in Freiburg, then take the 19:15 DB Regio AG Baden-Württemberg train on to Colmar (46 min). You arrive in Colmar around 20:01. In total it's roughly EUR 84 over 11h 51m, 2 transfers.
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Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Fly into Zurich, then continue to Colmar by bus (2h) — routing via Zurich keeps the trip simple. Flight (VF, 3h 10min) + Bus (FlixBus, 2h) via Zurich + Train (DB Regio AG Baden-Württemberg, 46min) via Freiburg.