Start with the 07:00 FlixBus bus from Brno to Sibiu, about 14h 41m. Transfer in Sibiu, then take the 07:00 (+1d) FlixBus bus on to Bucharest (4h 25m). Transfer in Bucharest, then take the 13:30 (+2d) FlixBus bus on to İstanbul Esenler (11h 10m). You arrive in İstanbul Esenler around 00:40 (+2d). In total it's roughly EUR 182 over 41h 40m, 2 transfers.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Ground-only route to İstanbul Esenler by bus. Bus (FlixBus, 14h 41min) + Bus (FlixBus, 4h 25min) via Sibiu + Bus (FlixBus, 11h 10min) via Bucharest.