Start with the 13:35 AJet flight from Istanbul to Brussels, about 3h 35m. Transfer in Brussels, then take the 18:40 Regional connection bus on to Maastricht (2h 8m). Transfer in Liege, then take the 07:30 (+1d) FlixBus bus on to Luxembourg (2h 5m). You arrive in Luxembourg around 09:35 (+1d). In total it's roughly EUR 96 over 20h, 3 transfers.
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Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Fly into Brussels, then continue to Luxembourg by bus (2h 8m) — routing via Brussels keeps the trip simple. Flight (VF, 3h 35min) + Bus (Regional connection, 2h 8min) via Brussels + Bus (FlixBus, 2h 5min) via Liège Guillemins.