Start with the 05:00 Regional connection bus from Niğde to Kayseri, about 2h 34m. Transfer in Kayseri, then take the 09:15 FlixBus bus on to Ankara (4h 10m). Transfer in Ankara, then take the 16:00 flight on to Frankfurt (3h). You arrive in Frankfurt around 19:00. In total it's roughly EUR 225 over 14h, 2 transfers.
Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
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Fly into Niğde, then continue to Frankfurt by bus (2h 34m) — routing via Niğde keeps the trip simple. Bus (Regional connection, 2h 34min) + Bus (FlixBus, 4h 10min) via Kayseri + Flight (3h) via Ankara.