Start with the 05:00 Regional connection train from Istanbul to Eskişehir, about 2h 16m. Transfer in Eskişehir, then take the 09:15 FlixBus bus on to Gebze (3h 45m). Transfer in Gebze, then take the 15:30 FlixBus bus on to İstanbul Dudullu (25 min). Transfer in İstanbul Dudullu, then take the 17:45 (+1d) FlixBus bus on to Şanlıurfa (16h 30m). Transfer in Şanlıurfa, then take the 12:05 (+1d) Regional connection bus on to Adıyaman (1h 24m). You arrive in Adıyaman around 13:29 (+1d). In total it's roughly EUR 192 over 32h 29m, 4 transfers.
Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
FlixBusOpens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Ground-only route to Adıyaman by train + bus. Train (Regional connection, 2h 16min) + Bus (FlixBus, 3h 45min) via Eskişehir + Bus (FlixBus, 25min) via Gebze + Bus (FlixBus, 16h 30min) via İstanbul Dudullu + Bus (Regional connection, 1h 24min) via Şanlıurfa.