Start with the 07:05 Turkish Airlines flight from Istanbul to Cologne, about 3h 20m. Transfer in Cologne Airport CGN, then take the 15:30 FlixBus bus on to Wittlich (2h 30m). Transfer in Wittlich, then take the 20:15 FlixBus bus on to Luxembourg (1h 25m). You arrive in Luxembourg around 21:40. In total it's roughly EUR 128 over 15h 30m, 2 transfers.
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Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Fly into Cologne Airport CGN, then continue to Luxembourg by bus (2h 30m) — routing via Cologne Airport CGN keeps the trip simple. Flight (Turkish Airlines, 3h 20min) + Bus (FlixBus, 2h 30min) via Cologne Airport CGN + Bus (FlixBus, 1h 25min) via Wittlich.