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How to travel this route
Start with the 07:30 FlixBus bus from Vienna to Vienna Matzleinsdorferplatz, about 25 min. Transfer in Vienna, then take the 18:25 (+1d) Ryanair flight on to Prague (5h 35m). You arrive in Prague around 00:00 (+1d). In total it's roughly EUR 87 over 11h, 2 transfers.
Your journey, leg by leg
BusFlixBusHIGH
Vienna → Vienna Matzleinsdorferplatz
€907:30 → 07:5525m
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Transfer in Vienna Matzleinsdorferplatz
BusLocal busHIGH
Vienna Matzleinsdorferplatz → Vienna International VIE
€708:45 → 09:3045m
Transfer in Vienna
FlightRyanairMEDIUM
Vienna International VIE → Prague Václav Havel PRG
€7118:25 → 00:00+1d5h 35m
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About this route
Fly into Vienna, then continue to Prague by bus (25 min) — routing via Vienna keeps the trip simple. Bus (FlixBus, 25min) + Flight (Ryanair, 5h 35min) via Vienna.