Start with the 09:25 Wizz Air flight from Istanbul to Budapest, about 2h. Transfer in Budapest, then take the 15:30 FlixBus bus on to Vienna (2h 40m). Transfer in Vienna, then take the 18:25 (+2d) Ryanair flight on to Prague (5h 35m). You arrive in Prague around 00:00 (+2d). In total it's roughly EUR 135 over 19h 3m, 3 transfers.
Kiwi opens sorted by price, cheapest first. Final fare is confirmed at checkout.
Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Kiwi opens sorted by price, cheapest first. Final fare is confirmed at checkout.
Fly into Budapest, then continue to Prague by bus (2h 40m) — routing via Budapest keeps the trip simple. Flight (Wizz Air, 2h) + Bus (FlixBus, 2h 40min) via Budapest + Flight (Ryanair, 5h 35min) via Vienna.