Start with the 07:05 Turkish Airlines flight from Istanbul to Cologne, about 3h 20m. Transfer in Cologne Airport CGN, then take the 15:30 FlixBus bus on to Essen central (1h 35m). Transfer in Essen central, then take the 17:45 FlixBus bus on to Düsseldorf central (35 min). You arrive in Düsseldorf central around 18:20. In total it's roughly EUR 125 over 14h 10m, 2 transfers.
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Opens Omio — enter your date to compare trains and buses for this route; the price is finalised at checkout.
Fly into Cologne Airport CGN, then continue to Düsseldorf central by bus (1h 35m) — routing via Cologne Airport CGN keeps the trip simple. Flight (Turkish Airlines, 3h 20min) + Bus (FlixBus, 1h 35min) via Cologne Airport CGN + Bus (FlixBus, 35min) via Essen central.